张丽媛

职称职务：副教授

邮箱：LiyuanZhang@bjut.edu.cn

基本信息

张丽媛，北京工业大学太阳贵宾会2017生物医学工程系副教授，硕士生导师。2020年博士毕业于北京航空航天大学一般力学与力学基础专业，校级优秀博士学位论文获得者，国家公派联合培养博士研究生（英国伦敦大学学院），英国大奥蒙德街儿童医院助理研究员。主要研究方向为神经与智能系统动力学、非线性振动及控制、脑血流动力学。在神经系统疾病动力学建模及控制方面，特别是在癫痫疾病发作的临床病理机制、动力学演化规律和调控策略等方面取得一定成果。近五年主持国家自然科学基金面上项目、青年项目、国家重点研发计划子课题、中国博士后基金面上项目、北京市博士后基金项目、企业横向项目等，作为骨干成员参与国家自然科学基金重点项目、面上项目，国家重点研发计划等。在Nonlinear Dynamics、 Chaos、Artificial Intelligence in Medicine、Journal of Cerebral Blood Flow & Metabolism、IEEE Transactions on Neural Systems and Rehabilitation Engineering等高水平期刊发表SCI论文30余篇、授权专利一项、软件著作权一项。兼任全国神经动力学学术会议委员、中国力学学会会员、中国振动工程学会会员、中国生物医学工程学会会员、中国神经科学学会会员、北京市脑网络组与类脑智能学会会员，SCI期刊Cognitive Neurodynamics编委。

研究方向

神经与智能系统动力学、非线性振动及其控制、脑血流动力学

科研项目

（1）国家自然科学基金面上项目,神经血流交互的卒中后癫痫动力学机制解析与调控策略研究,主持，2026.1-2029.12

（2）科技部重点研发计划项目子课题，基于缺血性脑疾病的神经血管耦合调控的流体动力学建模，主持，2021.12-2026.11

（3）国家自然科学基金青年项目，癫痫的海马网络动力学建模与超声刺激调控机制分析，主持，2022.1-2024.12

（4）中国博士后科学基金面上项目，局灶性癫痫海马网络超同步型发作的动力学建模及机制分析，主持，2021.8-2022.7

（5）北京市博士后科学基金项目，海马癫痫样后放电网络动力学建模与光遗传调控机制分析，主持，2021.3-2022.7

（6）国家自然科学基金面上项目，冠脉CT血流储备分数无创计算的可解释高精度深度学习，骨干，2023.1-2026.12

（7）国家自然科学基金重点项目，颞叶癫痫致痫灶动力学建模分析与控制及在诊疗评估中的应用，骨干，2020.1-2024.12

（8）英国Great Ormond Street Hospital for Children NHS Trust项目，Machine Learning for Intracranial EEG Analysis in Pediatric Epilepsies，骨干，2019.8-2020.7

获奖情况

立德树人毕业班优秀班主任标兵、就业创业工作先进个人、连续三年立德树人优秀班主任、优秀硕士学位论文指导教师

代表性研究成果

【近五年代表性学术论文及专利】

(1) Tongna Wang, Youjun Liu, Bao Li, Ruoyao Xu, Yuejuan Xu, Yang Yang, Yili Feng, Liyuan Zhang^*. Dynamical insights from a heterogeneous whole-brain model of pre vs. post visual-motor task[J]. Cognitive Neurodynamics, 2025, 19(1):153.

(2) Tongna Wang, Bao Li, Youjun Liu, Ruoyao Xu, Yuejuan Xu, Yang Yang, Liyuan Zhang^*. Complex visual cognitive function based on a large-scale neurovascular and metabolic coupling mechanisms model in whole brain[J]. Electronic Research Archive, 2025, 33(4):2412-2432.

(3) Hao Sun, Junling Ma, Bao Li, Youjun Liu, Jincheng Liu, Xue Wang, Gerold Baier, Jian Liu, Liyuan Zhang^*. Estimation of central aortic pressure waveforms by combination of a meta-learning neural network and a physics-driven method[J]. International Journal for Numerical Methods in Biomedical Engineering, 2025, 41(1):e3905.

(4) Liyuan Zhang, Yuejuan Xu, Gerold Baier, Youjun Liu, Bao Li^*. Exploring the dynamical transitions on an epileptic hippocampal network model and its modulation strategy based on transcranial magneto-acoustical stimulation[J]. Nonlinear Dynamics, 2024, 112(11):9495-9513.

(5) Liyuan Zhang, Zhiyuan Ma, Ying Yu, Bao Li, Shuicai Wu, Youjun Liu^*, Gerold Baier^*. Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus[J]. Cognitive Neurodynamics, 2024, 18(1):265-282.

(6) Yili Feng, Ruisen Fu, Hao Sun, Xue Wang, Yang Yang, Chuanqi Wen, Yaodong Hao, Yutong Sun, Bao Li, Na Li, Haisheng Yang, Quansheng Feng, Jian Liu, Zhuo Liu, Liyuan Zhang^*, Youjun Liu^*. Non-invasive fractional flow reserve derived from reduced-order coronary model and machine learning prediction of stenosis flow resistance[J]. Artificial Intelligence in Medicine, 2024, 147:102744.

(7) Zhiyuan Ma, Yuejuan Xu, Gerold Baier, Youjun Liu, Bao Li, Liyuan Zhang^*. Dynamical modulation of hypersynchronous seizure onset with transcranial magneto-acoustic stimulation in a hippocampal computational model[J]. Chaos: An Interdisciplinary Journal of Nonlinear Science, 2024, 34(4): 043107.

(8) Yili Feng, Bao Li, Ruisen Fu, Yaodong Hao, Tongna Wang, Huanmei Guo, Junling Ma, Gerold Baier, Haisheng Yang, Quansheng Feng, Liyuan Zhang^*, Youjun Liu^*. A simplified coronary model for diagnosis of ischemia-causing coronary stenosis[J]. Computer Methods and Programs in Biomedicine, 2023, 242:107862.

(9) Bao Li, Youjun Liu, Jinchen Liu, Hao Sun, Yili Feng, Zhe Zhang, Liyuan Zhang^*. Cerebral multi-autoregulation model based enhanced external counterpulsation treatment planning for cerebral ischemic stroke[J]. Journal of Cerebral Blood Flow & Metabolism, 2023, 43(10):1764-1778.

(10) Liyuan Zhang, Qingyun Wang, Baier Gerold^*. Spontaneous transitions to focal-onset epileptic seizures: A dynamical study[J]. Chaos, 2020,30(10), 103114.

(11) Liyuan Zhang, Qingyun Wang, Baier Gerold^*. Dynamical features of a focal epileptogenic network model for stimulation-based control[J]. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2020, 28(8), 1856-1865.

(12) 张丽媛，王同娜，刘有军，李鲍. 一种基于神经血管耦合的脑血流量预测系统. 中国发明专利，专利号：ZL202310580124.0，授权日：2024-01-26

【近五年国内外学术交流】

(1) Liyuan Zhang^*, Yuejuan Xu, Youjun Liu, Tongna Wang, Zichang Wang. Modeling and analysis of epileptic dynamics via neuro-glia-vascular coupling. The 9th International Conference on Vibration Engineering (ICVE 2025), Nanjing, China, 24-26 Oct.2025. (Best Presentation)

(2) 张丽媛^*，刘有军，王同娜，许若垚，李鲍.基于神经血管耦合的脑功能及其病态 机制解析. 中国力学大会-2025，中国长沙，2025.7.18-21.

(3) Liyuan Zhang^*, Qingyun Wang, Gerold Baier, Youjun Liu. Generation of the low-voltage fast seizure-onset and its opto-neuromodulation in a hippocampal network model. The 6th International Conference on Dynamics, Vibration and Control (ICDVC 2022+1), Shanghai, China, 7-9Apr.2023. (Session chair)

(4) Liyuan Zhang, Qingyun Wang^*, Gerold Baier, Youjun Liu. Dynamic Oscillation and Fraction Modulation Strategy of a Focal Epileptogenic Network Model. The 8th International Conference on Vibration Engineering (ICVE 2021), Shanghai, China, 24-26Jul.2021. (Invited speaker)

(5) Liyuan Zhang, Youjun Liu^*, Gerold Baier, Qingyun Wang, Friederike Moeller. A dynamical model of focal-onest seizures organizing the parameter space of epileptic dynamics.首届前沿交叉优秀博士后论坛，中国北京，2020.12.

招生要求

0831生物医学工程02方向；085409 (专业学位)生物医学工程02方向

有一定的编程能力，在数学、英语方面有扎实的基础，积极认真，具有独立思考解决复杂问题的能力。

联系方式

邮箱：LiyuanZhang@bjut.edu.cn

通讯地址：北京市朝阳区平乐园100号北京工业大学生命楼B527