李春华

教授

chunhuali@bjut.edu.cn

基本信息

北京工业大学太阳贵宾会2017教授，中国生物信息学学会(筹)生物分子结构预测和模拟专业委员会委员，北京市科技新星，北京市优秀人才。主要从事生物物理和生物信息学方面的研究。2012、2015-2016在美国密歇根大学计算医学与生物信息学系Yang Zhang教授课题组访问工作。曾主持多项国家自然科学基金项目，参加国家自然科学基金重大项目、科技部国际科技合作交流项目。近年来，在国内外重要学术期刊，如Structure,Journal of physical chemistry letters,BiophysicalJ,Briefings in Bioinformatics等上发表多篇论文。

研究方向

蛋白质变构动力学

蛋白质-蛋白质/核酸/小肽相互作用与识别

生物大分子结构-功能关系

与重大疾病有关的医疗大数据分析

主要科研项目/课题

国家自然科学基金项目：基于全原子和粗粒化模型的蛋白质-RNA相互作用动力学及功能性构象变化的研究 (31971180)

国家自然科学基金项目：基于多尺度分子动力学模拟和网络模型的ABC转运蛋白变构机制的研究（11474013）

国家自然科学基金项目：基于RNA分子柔性分析的蛋白质-RNA分子对接方法研究（31171267）

国家自然科学基金项目：蛋白质功能位点预测方法的研究（20773006）

北京市自然科学基金项目：蛋白质-RNA特异性识别预测及在抗HIV环肽研究中的应用（4152011），

北京市自然科学基金项目：基于蛋白拓扑结构及动力学信息的结合位点预测方法研究（4102006）

代表性成果

[1] Zhixiang Wu, Xiaohan Sun, Jingjie Su, Xinyu Zhang, Chunhua Li*. Molecular insights into the unique activation and allosteric modulation mechanisms of the human mas-related G-protein-coupled receptor X1.International Journal of Biological Macromolecules. 2025; 317:144815.

[2]Fangrui Hu, Fubin Chang, Lianci Tao, Xiaohan Sun, Lamei Liu, Yingchun Zhao, Zhongjie Han, Chunhua Li*. Prediction of protein allosteric sites with transfer entropy and spatial neighbor-based evolutionary information learned by an ensemble model.Journal of chemical information and modeling. 2024;64(15):6197-6204.

[3] Yingchun Zhao†, Xinyu Zhang†, Lamei Liu, Fangrui Hu, Fubin Chang, Zhongjie Han, Chunhua Li*. Insights into activation dynamics and functional sites of inwardly rectifying potassium channel Kir3.2 by an elastic network model combined with perturbation methods.Journal of Physical Chemistry B. 2024;128(6):1360-1370.

[4]Zhongjie Han, Xiaoli Wang, Zhixiang Wu, Chunhua Li*.Study of the allosteric mechanism of human mitochondrial phenylalanyl-tRNA synthetase by transfer entropy via an improved Gaussian Network Model and co-evolution analyses.Journal of physical chemistry letters.2023;14(14):3452-3460.

[5]Xiaohan Sun, Shuang Yang, Zhixiang Wu, Jingjie Su, Fangrui Hu, Fubin Chang, Chunhua Li*. PMSPcnn: predicting protein stability changes upon single point mutations with convolutional neural network.Structure. 2024;32(6):838-848.e3.

[6]Shuang Yang,Weikang Gong,Tong Zhou,Xiaohan Sun,Lei Chen,Wenxue Zhou,Chunhua Li*.emPDBA: protein-DNA binding affinity prediction by combining features from binding partners and interface learned with ensemble regression model.Briefings in bioinformatics.2023; 24(4):bbad192.

[7]Weikang Gong, Yang Liu, Yanpeng Zhao, Shihao Wang, Zhongjie Han, Chunhua Li*. Equally weighted multiscale elastic network model and its comparison with traditional and parameter-free models.Journal of chemical information and modeling.J Chem Inf Model. 2021;61(2):921-937.

[8]Tong Zhou^#, Jie Rong^#, Yang Liu, Weikang Gong,Chunhua Li^*. An ensembleapproachto predict binding hotspots inprotein-RNA interactionsbased on SMOTE data balancing and random grouping feature selectionstrategies.Bioinformatics.2022;38(9): 2452-2458.

[9]QiShao†, Zhongjie Han†, Jingmin Cheng, Qiankun Wang, Weikang Gong, Chunhua Li*. Allosteric mechanism of human mitochondrial phenylalanyl-tRNA synthetase: an atomistic MD simulation and a mutual information-based network study.Journal of Physical Chemistry B. 2021;125(28):7651-7661.

[10] Tong Zhou, Chunhua Li*.Single-cell transcriptome highlights a multilayer regulatory network on an invasive trajectory within colorectal cancer progression.Journal of cancer research and clinical oncology. 2022;148(9):2313-2322.

联系方式

E-mail： chunhuali@bjut.edu.cn