郭兵兵

职称职务：博士，硕士研究生导师

邮箱：guobingbing@bjut.edu.cn

教育背景

2013.09-2019.07  北京大学 能源与资源工程 博士

2017.10-2018.12  瓦赫宁根大学 农业技术与食品科学 联合培养博士

2009.09-2013.07 吉林大学 食品科学与工程 本科

工作经历

2019.07-至今 北京工业大学 环境与生命学部

研究方向

1. 肠道菌群对天然产物/膳食因子等化合物的消化代谢

2. 天然产物等调控肠道菌群及代谢物对肥胖、炎症等的干预及“未病”的防控

3. 益生菌的靶向稳态化递送

课程教学

本科生课程：普通生物学

本科生课程：营养学

研究生课程：生物化学

研究生课程：生物医学工程与转化研究

主要科研项目

北京市自然科学基金：基于仿生人体肠芯片探究肠道菌群源SCFAs对肠上皮细胞紧密连接的调控机制，2024-2025，主持

北京市自然科学基金：基于仿生人体肠芯片探究肠道菌群源SCFAs对肠上皮细胞紧密连接的调控机制

中国博士后面上项目：基于粪便代谢组学研究岩藻黄素干预小鼠肥胖的作用机理

北京市博士后基金：基于代谢组学研究岩藻黄素对非酒精性脂肪肝的干预机理

朝阳区博士后基金：岩藻黄素在人体内的消化代谢及菌群发酵动力学研究

北京教科委基础研究基金：三角褐指藻岩藻黄素在人体内的消化吸收与粪菌代谢

代表性研究成果

1. Guo,B., et al. “β-1,3-glucans from Euglena Gracilis protects against ulcerative colitis via modulating the gut barrier, T-cell immunity and gut microbiota” International Journal of Biological Macromolecules. (2025): 305,141288

2. Guo,B., et al. Euglena gracilis polysaccharide modulated gut dysbiosis of obese individuals via acetic acid in an in-vitro fermentation model. Food Research International. (2025): 199, 115385.

2. Guo,B., et al. "Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review." Critical Reviews in Food Science and Nutrition (2025): 65, 265-286.

4. Guo,B., et al. “Microalgae-derived carotenoids: Digestive fate and interplay with gut microbiota" Trends in Food Science & Technology. (2024): 153,104760

5. Guo,B., et al. "Fucoxanthin restructures the gut microbiota and metabolic functions of non-obese individuals in an in vitro fermentation model." Food & Function. (2024): 15,4805

6. Zhou, Yonghui,...Guo,B.* "Fucoxanthin improves serum lipids, liver metabolism and gut microbiota in hyperlipidemia mice." Food Science and Human Wellness. (2024): 14, 9250017

7. Guo,B., et al. "Lipid-lowering bioactivity of microalga Nitzschia laevis extract containing fucoxanthin in murine model and carcinomic hepatocytes.” Pharmaceuticals 14.10 (2021): 1004.

8. Guo,B., et al. "Extract of the microalga Nitzschia laevis prevents high‐fat‐diet‐induced obesity in mice by modulating the composition of gut microbiota.” Molecular Nutrition & Food Research. 63.3 (2019): 1800808.

9. Guo,B., et al. "Fucoxanthin modulates cecal and fecal microbiota differently based on diet." Food & Funcion. 10.9 (2019): 5644-5655.

10. Guo,B., et al. "Gastrointestinal bioaccessibility and colonic fermentation of fucoxanthin from the extract of the microalga Nitzschia laevis." Journal of Agricultural and Food Chemistry. 68.7 (2019): 1844-1850.