徐坤

职称职务：教授 博士生导师

邮箱：kunxu@bjut.edu.cn

基本信息

中国科学技术大学与Rutgers University 联合培养博士，2014年获有机化学博士学位，导师汪志勇教授，张绪穆教授。现任北京工业大学教授，博士生导师。主持面上项目等国家自然科学基金三项，以通讯作者在Angewandte Chemie, CCS Chemistry, Science Bulletin, Science China Chemistry, Chemical Science，等期刊上发表研究论文50余篇，其中ESI热点文章2篇，ESI高被引论文7篇。多次入选 “全球前2%顶尖科学家榜单”。兼任催化联盟青年工作委员会委员，Chin. J. Org. Chem.青年编委。

研究方向

电化学有机合成，药物分子绿色合成工艺

科研项目

基于LMCT机制的难氧化高键能化学键的电化学氧化活化研究（国家自然科学基金 2022-2025）

钴催化的羧酸化合物的脱羧胺化反应研究（国家自然科学基金2017-2019）

电化学诱导的自由基加成反应在含氮稠杂环合成中的应用（国家自然科学基金2016-2018）

近五年部分通讯作者论文

1. Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway. J. Catal., 2020, 381, 38–43.

2. Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2. Org. Lett., 2020, 22, 3570–3575.

3. Electrochemical synthesis of selenocyanated imidazo[1,5-a]quinolines under metal catalyst- and chemical oxidant-free conditions. Chin. Chem. Lett., 2020, 31, 1576-1579.

4. Recent advances in organic electrosynthesis employing transition metal complexes as electrocatalysts. Sci. Bull. 2021, 66, 2412-2429.

5. Regioselective C–H Phosphorothiolation of (Hetero)arenes Enabled by the Synergy of Electrooxidation and Ultrasonic Irradiation. Org. Lett., 2021, 23, 4214–4218.

6. Access to Deuterated Unnatural α-Amino Acids and Peptides by Photochemical Acyl Radical Addition. Org. Lett., 2021, 23, 5299–5304.

7. Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis. Angew. Chem. Int. Ed., 2021, 60, 7275-7282.

8. Tandem Strecker/C(sp3)–H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH4SCN as a cyanating agent. Org. Chem. Front., 2021, 8, 6384-6389.

9. Regioselective intramolecular sp2 C–H amination: direct vs. mediated electrooxidation. Org. Chem. Front., 2021, 8, 1581-1586.

10. Recent Applications of Homogeneous Catalysis in Electrochemical Organic Synthesis. CCS Chem. 2022, 4, 1120-1152.

11. Electrochemical Organoselenium-Catalyzed Intermolecular Hydroazolylation of Alkenes with Low Catalyst Loadings. Org. Lett. 2022, 24, 5345-5350.

12. Electrophotocatalytic C−H Functionalization of N-Heteroarenes with Unactivated Alkanes under External Oxidant-Free Conditions. ChemSusChem 2022, 15, e202102360.

13. Electrophotocatalytic Si–H Activation Governed by Polarity-Matching Effects. CCS Chem. 2022, 4, 1796-1805.

14. The synergism of sequential paired electrosynthesis with halogen bonding activation for the cyclization of organochlorides with olefins. Sci. Chin. Chem. 2023, 66, 540-547.

15. Electrophotoredox/cerium-catalyzed unactivated alkanes activation for the sustainable synthesis of alkylated benzimidazo-fused isoquinolinones. J. Catal., 2023, 417, 473–480.

16. Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis. Chem. Commun., 2023, 59, 12763-12766.

17. Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis. Adv. Synth. Catal., 2023, 365, 871-876.

18. Electrochemical Atom Transfer Radical Addition of Polychloroalkanes to Olefins Promoted by 4,4-Di-tert-butyl Bipyridine. Chin. J. Chem., 2023, 41, 1583-1588.

19. Electrochemical Umpolung Enabled Radical–Radical Cross-Coupling Between Electron-Deficient Methylarenes and Aldehydes. CCS Chem. 2023, 5, 1973-1981.

20. Paired Electrolysis Enabled Trifluoromethylheteroaromatization of Alkenes and Alkyne with Trifluoromethyl Thianthrenium Triflate as a Bifunctional Reagent. Org. Lett. 2024, 26, 411−415.

21. Visible-Light-Mediated Photocatalyst-Free Hydroacylation of Azodicarboxylic Acid Derivatives with 4-Acyl-1,4-dihydropyridines. Chin. J. Chem., 2024, 42, 1230-1236.

22. Electrochemical radical-polar crossover: a radical approach to polar chemistry. Sci. Chin. Chem. 2024, 67, 450-470.

23. Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview. Green Chem. 2024, 26, 8161–8203.

24. The merger of electro-reduction and hydrogen bonding activation for a radical Smiles rearrangement. Chem. Sci. 2024, 15, 13459–13465.

25. Electrophotochemical ligand-to-metal charge transfer catalysis: an emerging platform for sustainable synthesis. Green Chem. 2024, DOI: 10.1039/D5GC00186B.

招生方向

博士：生物医学工程 06药物合成与新技术应用; 化学

硕士：化学（学硕），生物与医药 （专硕）